Understanding mitral regurgitation

Discover what causes a leaky mitral valve and how it can affect your health.

Mitral regurgitation overview

A small leak in the mitral valve can make a big difference for your heart

Your heart keeps blood moving through your body. It sends blood to your lungs to pick up oxygen, then pumps it back out to deliver that oxygen everywhere it’s needed. The heart has 4 chambers and small valves that work like one-way doors, opening and closing to keep blood moving in the right direction. 

When someone has mitral regurgitation, the mitral valve doesn’t close completely. This leads to some blood leaking backward instead of moving forward. That is why mitral regurgitation is also known as “a leaky mitral valve” or “a leaky heart valve.” 

To keep up with the leak, your heart works harder to move blood through your body. Over time, this strain can lead to other heart complications, including new or worsening heart failure.

See how a leaky heart valve affects blood flow and what it means for your heart health.

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See how a leaky heart valve affects blood flow and what it means for your heart health.

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Read more about the 2 types of mitral regurgitation and treatment options in this downloadable guide.

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Read more about the 2 types of mitral regurgitation and treatment options in this downloadable guide.

Download

Types and Causes

There are 2 main types of mitral regurgitation

Primary mitral regurgitation (degenerative)

Caused by an abnormality in the valve itself, such as a birth defect, mitral valve prolapse (also known as MVP), age-related changes, or rheumatic fever.

Secondary mitral regurgitation (functional)

Caused by heart disease that enlarges the left ventricle or atrium, stretching the valve and preventing it from closing fully. This type of mitral regurgitation is most common in people with heart failure.

Symptoms

Mitral regurgitation symptoms can vary

Some people feel no symptoms for years, while others notice them right away. The most commonly reported symptoms of 
mitral regurgitation may include1-4:

Fatigue or low energy

Shortness of breath

Heart palpitations

Recurrent cough

Swollen feet or ankles

Lightheadedness or fainting

If you notice any of these symptoms, or your symptoms worsen, talk to your doctor. 
A thorough exam can help determine if mitral regurgitation may be the cause.

Treatments

Protecting your heart’s future

Without treatment, mitral regurgitation can worsen over time, leading to reduced heart pumping function, and other serious complications. Treatments for mitral regurgitation are designed to reduce strain on your heart and lungs and help your heart pump blood more efficiently. Getting the right treatment early can help protect and restore your heart's function, and significantly improve your day-to-day life. In heart failure patients, a 5-year study showed that earlier treatment with MitraClip Therapy saved lives and reduced heart failure hospitalizations.5

If left untreated, up to 57% of heart failure patients with a leaky mitral valve may not survive past 1 year.6

Treatment options for mitral regurgitation include:

Medications

For heart failure patients, medications are often the first treatment, and some patients do improve with medication. In patients with a damaged mitral leaflet, medications are often not adequate because they do not repair the valve itself. There are a variety of medications available to help manage your mitral regurgitation. Your doctor will recommend the right regimen for your needs.

MitraClip™ Therapy

For some people, medications may not be enough to relieve symptoms, while others may be too sick for open-heart surgery. MitraClip Therapy offers a safe, minimally invasive option for correcting mitral regurgitation by repairing the valve and helping it close properly.

Learn More

Surgical repair or replacement

If you're not a candidate for a minimally invasive therapy, your doctor may recommend surgical valve repair or replacement with an artificial (prosthetic) valve. Each surgical approach offers different benefits and risks, depending on your specific needs.

Discuss all treatment options with your doctor

Your doctor can describe the risks and benefits and help you decide which option is right for you.

Is MitraClip Therapy right for me?

Use our quick questionnaire to see if you might be a candidate for MitraClip Therapy.

Start Questionnaire

Ready to discuss with your doctor?

If your mitral regurgitation symptoms are interrupting your daily life, download this discussion guide to prepare for your next doctor’s appointment.

Download Discussion Guide

Important Safety Information

What is MitraClip™ Therapy approved for?

Available by prescription only.

MitraClip therapy is a minimally invasive procedure approved for treating patients with clinically significant mitral regurgitation due to either (a) a deteriorated mitral valve in patients who are deemed to be at prohibitive risk for surgery, or (b) mitral valve in patients who have heart failure and reduced pumping function who remain symptomatic despite maximally tolerated medications to treat their heart failure.

Patients should work with their doctor and a multidisciplinary heart team, which may include a heart surgeon and cardiologist with experience treating heart failure, to confirm their surgical risk and to ensure that they are on the optimal medications. The heart team will determine if transcatheter edge-to-edge valve repair is clinically appropriate, and if the patient meets the indications for the MitraClip procedure.

Who should not have the MitraClip Procedure?

Patients that have any of the following conditions may not be good candidates for the MitraClip Procedure: Patients with intolerance or allergy to procedural anticoagulation, untreatable hypersensitivity to implant components (nickel-titanium alloy, cobalt-chromium alloy), or active endocarditis or other active infection of the mitral valve.

What are the possible complications associated with the MitraClip Procedure?

As with any medical procedure, there is a possibility of complications. The most serious complications of the MitraClip procedure includes, but are not limited to: death, stroke (a condition in which decreased blood flow to the brain can result in brain damage and may cause severe disability), transient ischemic attack (stroke symptoms that last only a few minutes), major vascular complications (damage to a major blood vessel that may require emergency surgery or urgent cardiac surgery), life threatening bleeding event (a major bleeding event that requires a blood transfusion).  For additional potential risks and complications, please consult with your physician or heart team.

Talk to your doctor to learn more about the risks associated with MitraClip Therapy and ask for the detailed Important Safety Information if you'd like to review the full list of complications.

References:

  1. Mayo Clinic. Mitral valve regurgitation. Accessed December 16, 2025. https://www.mayoclinic.org/diseases-conditions/mitral-valve-regurgitation/symptoms-causes/syc-20350178
  2. Cleveland Clinic. Can a cough be related to heart issues? May 5, 2022. Accessed December 16, 2025. https://health.clevelandclinic.org/persistent-cough-it-may-be-a-sign-of-heart-failure
  3. Phoenix Heart. 6 symptoms of mitral regurgitation. October 6, 2022. Accessed December 16, 2025. https://phoenixheart.com/6-symptoms-of-mitral-regurgitation/
  4. Stone GW. COAPT: a randomized trial of transcatheter mitral valve leaflet approximation in patients with heart failure and secondary mitral regurgitation. Slide presented at: TCT 2018; September 21-25, 2018; San Diego, CA. 
  5. Stone GW et al. Five-year follow-up after transcatheter repair of secondary mitral regurgitation. N Engl J Med. 2023;388(22):2037-2048
  6. Cioffi G et al. Functional mitral regurgitation predicts 1-year mortality in elderly patients with systolic chronic heart failure. Eur J Heart Fail. 2005;7(7):1112-1117.

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