About MitraClip™ Therapy

Learn about a simple, proven way to fix your leaky mitral valve.

MitraClip Therapy Overview

Understanding MitraClip Therapy

Fixing your mitral valve leak without open-heart surgery

MitraClip Therapy requires a simple, minimally invasive procedure that repairs your mitral valve. During the procedure, the healthcare professional guides a thin tube (called a catheter) through a vein in your groin to reach your heart. A small clip, about the size of a dime, is attached to the leaflets of your mitral valve to help it close more completely. This allows blood to flow on both sides of the clip into the left ventricle while reducing or preventing blood from flowing backward into the left atrium.

The MitraClip procedure typically takes 1 to 3 hours and allows for a shorter recovery time than open-heart surgery. Most people return home after one day in the hospital and often feel improvement soon after, resuming regular activities within 1 to 2 weeks.

Results

MitraClip Therapy is proven safe and effective

With more than 20 years of proven outcomes and experience in over 200,000 people worldwide, MitraClip Therapy has been shown to safely and effectively reduce mitral regurgitation, improve survival, reduce hospitalizations, and help patients feel better.

In large clinical studies:

47%

fewer heart failure hospitalizations
after 5 years compared to medication alone

28%

lower risk of death than those treated with medication alone

99%

of people were free from device-related complications at 5 years

2x

more likely to see major improvements in quality of life compared to medication alone

Is MitraClip Therapy for me?

Use our quick self-assessment to see if this minimally invasive heart procedure could be right for you.

Start Assessment

Ready to discuss with your doctor?

If your mitral regurgitation symptoms are interrupting your daily life, download this discussion guide to prepare for your next doctor’s appointment.

Download Discussion Guide

Find a cardiologist near me

Meet with a specialized care team experienced with the MitraClip™ procedure.
Important Safety Information
Important Safety Information

What is MitraClip™ Therapy approved for?

Available by prescription only.

MitraClip therapy is a minimally invasive procedure approved for treating patients with clinically significant mitral regurgitation due to either (a) a deteriorated mitral valve in patients who are deemed to be at prohibitive risk for surgery, or (b) mitral valve in patients who have heart failure and reduced pumping function who remain symptomatic despite maximally tolerated medications to treat their heart failure.
Patients should work with their doctor and a multidisciplinary heart team, which may include a heart surgeon and cardiologist with experience treating heart failure, to confirm their surgical risk and to ensure that they are on the optimal medications. The heart team will determine if transcatheter edge-to-edge valve repair is clinically appropriate, and if the patient meets the indications for the MitraClip procedure.

Who should not have the MitraClip Procedure?

Patients that have any of the following conditions should not have the MitraClip Procedure: inability to tolerate or are allergic or hypersensitive to anti-coagulants, anti-platelet therapies, nickel, titanium, cobalt, chromium, polyester, or contrast dye; have inflammation or rheumatic disease of the valve; have blood clots inside the heart or blood vessels (inferior vena cava, femoral vein), or active endocarditis or other active infection of the valve or have mitral or tricuspid valve anatomy which is deemed not suitable for repair with MitraClip.

What are the possible complications associated with the MitraClip Procedure?

As with any medical procedure, there is a possibility of complications. The most serious complications of the MitraClip procedure includes, but are not limited to: death, stroke (a condition in which decreased blood flow to the brain can result in brain damage and may cause severe disability), transient ischemic attack (stroke symptoms that last only a few minutes), major vascular complications (damage to a major blood vessel that may require emergency surgery or urgent cardiac surgery), life threatening bleeding event (a major bleeding event that requires a blood transfusion). For additional potential risks and complications, please consult with your physician or heart team.

Talk to your doctor to learn more about the risks associated with MitraClip Therapy and ask for the detailed Important Safety Information if you’d like to review the full list of complications.

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MAT-200XXXX vX.X | Item approved for U.S. use only

References: 1. Stone GW. et al. Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation. N Engl J Med. March 5, 2023. DOI: 10.1056/NEJMOA2300213 2. Arnold SV et al. Health status after transcatheter mitral valve repair in heart failure and secondary mitral regurgitation. JACC Mar 2019, 25951; DOI: 10.1016/j.jacc.2019.02.010 3. Mayo Clinic. Mitral valve regurgitation. Accessed June 16, 2025. www.mayoclinic.org/diseases-conditions/mitral-valve-regurgitation/symptoms-causes/syc-20350178 4. Cleveland Clinic. Can a Cough Be Related to Heart Issues? May 5, 2022. Accessed June 16, 2025. https://health.clevelandclinic.org/persistent-cough-it-may-be-a-sign-of-heart-failure 5. Phoenix Heart | Vein | Vascular. 6 Symptoms of Mitral Regurgitation. October 6, 2022. Accessed June 16, 2025. https://phoenixheart.com/6-symptoms-of-mitral-regurgitation/ 6. Cioffi G, Tarantini L, De Feo S, et al. Functional mitral regurgitation predicts 1-year mortality in elderly patients with systolic chronic heart failure. Eur J Heart Fail. 2005;7(7):1112-1117.  7. von Bardeleben, R. et. al. Real-World Outcomes of Fourth-Generation Mitral Transcatheter Repair 30-Day Results From EXPAND G4. JACC: Cardiovascular Interventions, 2023. Vol. 16. No. 12. doi.org/10.1016/j.jcin.2023.05.013